A new arteriovenous fistula model to study the development of neointimal hyperplasia.
نویسندگان
چکیده
This study describes an alternative arteriovenous fistula (AVF) model in the rat in which the animals develop significant neointimal hyperplasia (NIH) not only at the distal anastomotic site, but also throughout the fistula body. This aortocaval fistula was established by anastomosing the distal end of the renal vein to the abdominal aorta after unilateral nephrectomy. The increased hemodynamic stress resulting from exposing the renal vein to the arterial circulation induced venous NIH as early as 7 days after surgery. This experimental AVF was characterized by the early lack of endothelium, the accumulation of proliferating vascular smooth muscle cells and the neovascularization of the fistula adventitia. In summary, we have described an informative animal model to study the pathobiology of NIH in native AVF.
منابع مشابه
Prediction of arteriovenous fistula stenosis and failure via in vivo inflammation and fibrin molecular imaging
Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملPrediction of arteriovenous fistula stenosis and failure via in vivo inflammation and fibrin molecular imaging
Dialysis Access is the “lifeline” for 1.5 million end-stage renal disease (ESRD) patients across the world. Effective hemodialysis treatment requires reliable large caliber vascular access. The preferred hemodialysis access is an arteriovenous fistula (AVF) because of its lower infection rate, lower hospitalization rate and relatively longer longevity compared to grafts.(1, 2) However, the prim...
متن کاملImproving arteriovenous fistula patency: Transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation
Creation of an autologous arteriovenous fistula (AVF) for vascular access in haemodialysis is the modality of choice. However neointimal hyperplasia and loss of the luminal compartment result in AVF patency rates of ~60% at 12months. The exact cause of neointimal hyperplasia in the AVF is poorly understood. Vascular trauma has long been associated with hyperplasia. With this in mind in our rabb...
متن کاملNovel paradigms for dialysis vascular access: downstream vascular biology--is there a final common pathway?
Vascular access dysfunction is a major cause of morbidity and mortality in hemodialysis patients. The most common cause of vascular access dysfunction is venous stenosis from neointimal hyperplasia within the perianastomotic region of an arteriovenous fistula and at the graft-vein anastomosis of an arteriovenous graft. There have been few, if any, effective treatments for vascular access dysfun...
متن کاملPericardial patch venoplasty heals via attraction of venous progenitor cells
Pericardial patches are commonly used during cardiovascular surgery to close blood vessels. In arteries, patches accumulate arterial progenitor cells; we hypothesized that venous patches would accumulate venous progenitor cells, in the absence of arterial pressure. We developed a novel rat inferior vena cava (IVC) venotomy model and repaired it with a pericardial patch. Cells infiltrated the pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of vascular research
دوره 49 2 شماره
صفحات -
تاریخ انتشار 2012